Study Of Serum Inorganic Phosphate Levels In Patients With Type Ii Diabetes Mellitus Admitted In Medical Icu And Wards In A Tertiary Care Centre

Abstract

BACKGROUND AND OBJECTIVES:

1. To study serum inorganic phosphate concentration in patients with type II diabetes mellitus without comorbidities.
2. To study serum inorganic phosphate concentration in patients with type II diabetes mellitus with comorbidities.
3. To compare serum inorganic phosphate levels in these two groups.

METHODOLOGY: 120 patients with type 2 diabetes mellitus were included in the study over 1 month from chettinad hospital and research institute, kelambakam , tamilnadu.

Blood samples were collected after a twelve-hour fasting period (Overnight fasting) under aseptic conditions, the obtained blood sample were centrifuged and plasma was separated. The plasma was analysed for the fasting and postprandial blood sugar, estimated by GOD-POD method10. Serum samples were separated from whole blood collected into tubes without anticoagulant, after clotting was complete, the tubes were then centrifuged for 10 minutes. Serum was removed and assayed for phosphorus. Patients will be considered diabetic according to the criteria defined by American Diabetes Association 2011 criteria.

RESULTS:

The present study was undertaken to determine the serum inorganic phosphate concentration in diagnosed cases of type 2 diabetes mellitus without comorbidities, type II diabetes mellitus with comorbidities like hypertension and ischemic heart disease and to compare between the two groups. Our study showed that serum inorganic phosphate concentration was reduced in 52% of the diagnosed cases of DM II without comorbidities and 21% of patients with DM II with comorbidities like HTN and IHD.

In the present study negative correlation was observed between serum inorganic phosphate levels and HbA1c, fasting and post prandial blood sugar levels in DM II patients with and without comorbidities. As long as glycaemic control was not attained decreased serum inorganic phosphate concentration may play a role in the progression of the disease and development of complications associated with diabetes mellitus.

CONCLUSION:

Serum phosphate levels were relatively more in patients with DM II with comorbidities like HTN and IHD than DM II without comorbidities.