In Vivo Study Of Phospholipid Naringenin Complex In Diabetes Treatment
Diabetes mellitus is an endocrinological and metabolic disorder with an increasing global prevalence and incidence. Many medicinal plants have been provided a potential source of anti-diabetic principles and are widely used for the treatment of diabetes mellitus. Naringenin a flavonoid Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. In addition, naringenin potentiates intracellular signalling responses to low insulin doses by sensitizing hepatocytes to ins Collulin. Thus this study evaluates the effect of Phospholipid complex of naringenin on various clinical parameters. Results showed that the Naringenin Phospholipid Complex at dose of (200 mg/kg) found to have body weight of 234.7±7.84 at 21 day. Also, the blood glucose level was observed to be 189.8±5.09 mg/dl for Naringenin PC complex. According to lipid profile outcomes the CHL, HDL, TG, DL were found to be 169.2±3.43mg/dl, 42.56±2.87 mg/dl, 166.7±3.60 mg/dl, 89.28±2.99mg/dl respectively for Polyherbal preparation (500 mg/kg). A significant fall in level of total cholesterol, triglycerides, LDL and VLDL in comparison to diabetic control was observed. However, HDL level was found to be increased as compared with untreated diabetic rats. In conclusion the Phospholipid naringenin complex have potential for treating diabetes.