Cardiovascular Health And Vitamin K Status: Evidence From Observational And Clinical Studie

Abstract

Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A increasing amount of research shows that vitamin K is good for bones and cardiovascular health. This review provides an overview of the most important research on the relationship between circulating vitamin K levels and cardiovascular outcomes. An essential matrix gla protein (MGP)-dependent inhibitor of vascular calcification. Vascular calcification and high amounts of uncarboxylated, dephosphorylated MGP have been linked, and vitamin K therapy can help. In this systematic review, we present the evidence that vitamin K supplementation improves surrogate markers of cardiovascular disease, such as calcification of the arteries and valves, atherosclerosis, and arterial stiffening. By searching Ovid MEDLINE, Embase, the Cochrane Central Registry of Controlled Trials, and the Web of Science Core Collection, researchers were able to find information from adult-specific controlled trials. Among nine randomised controlled trials, including trials of vitamin K1 or K2 supplementation, that evaluated a proxy for cardiovascular disease, such as arterial calcification, atherosclerosis, or arterial stiffening, we found nine studies that were suitable for review.