Biochemical changes in Oxidative stress in the Patient with primary open angle glaucoma with Diabetes mellitus

Abstract

Background: Primary glaucoma is a group of diseases characterised by abnormally high intraocular pressure (IOP), visual dysfunction, and optic nerve head cupping, and it is one of the leading causes of irreversible blindness worldwide. Oxidative stress appears to play a role in the progressive neuronal death seen in glaucomatous optic nerve damage.

Aim: To estimate biochemical study of antioxidant enzymes in the Patient with POAG with Diabetes mellitus and without POAG Diabetes mellitus as compared to control.

Methods: The present study was carried out in the Department of Biochemistry and Central Investigation Laboratory in collaboration with the Department of Ophthalmology. 100 diabetic patient Primary open-angle glaucoma patients, 100 diabetic without Primary open-angle glaucoma of both genders attending the Ophthalmology ward of the Hospital for the last one year have been included in this study as compared to 100 healthy control groups.

Results: The results showed a mean values of FBS, HbA1c were significantly increased (P<0.01) in Diabetes mellitus Patients Primary open-angle glaucoma, diabetes without Primary open-angle glaucoma cases as compared to normal healthy individuals. significantly decreased levels of antioxidant enzymes activity (SOD,  GR, GPx) levels in Diabetes mellitus with Primary open angle glaucoma, Diabetes without (POAG) as compared to the controls groups and significantly increased levels of MDA, Protein Corbonyl levels in Diabetes mellitus with Primary open angle glaucoma, Diabetes without (POAG) as compared to the controls groups (p<0.01).

Conclusion: The alteration of various antioxidant enzymes, and after this observation, we can suggest that early antioxidant enzyme investigation is a must in POAG diabetes cases. It is better to investigate antioxidant enzymes for better diagnosis and prognosis of the POAG in diabetes patients.