Skin Changes And Dermatological Life Quality Index In Chronic Kidney Disease (Ckd) Patients In Karachi Population

Abstract

Introduction: Chronic Kidney Disease (CKD) is a progressive and complex medical condition characterized by the gradual loss of kidney function over time. Objectives: The basic aim of the study is to find the skin changes and dermatological life quality index in chronic kidney disease (CKD) patients. Material and methods: This descriptive cross-sectional study was conducted in Institute of Skin Disease, Sindh, Karachi and Al-Khidmat Hospital, Karachi during October 2022 to May 2023. The study was approved by the Institutional Review Board (IRB) and informed consent was obtained from all participants. A total of 1000 CKD patients were enrolled in the study. Participants were selected based on the inclusion criteria, which included a confirmed diagnosis of CKD based on clinical and laboratory parameters. Patients with a history of primary dermatological conditions or those receiving active treatment for skin diseases were excluded from the study. Results: Data was collected from 1000 CKD patients. The mean age of the study participants is 55±9.87 years. The participants are divided into three age groups: 18-39 years, 40-59 years, and 60 years and above. 20% of the participants fall in the 18-39 years age group (200 individuals), 50% fall in the 40-59 years age group (500 individuals), and 30% fall in the 60 years and above age group. The table includes the prevalence of certain comorbidities among the study participants. According to the results, 70% of the participants have hypertension (700 individuals), 40% have diabetes (400 individuals), 25% have cardiovascular disease (250 individuals), and 30% have other comorbidities. It's important to note that individuals may have more than one comorbidity.  Conclusion: It is concluded that skin changes are prevalent among patients with chronic kidney disease (CKD), and they can have a significant impact on their dermatological life quality. This study investigated the association between DLQI grading, representing the impact on quality of life, and various skin changes in CKD patients.