Formulation And Evaluation Of Immediate Release And Modified Release Bilayer Tables Of Telmisartan And Metoprolol

Abstract

In the present investigation, efforts were made to develop immediate release and modified release bilayer tables of Telmisartan (TL) and Metoprolol (ML) for the treatment of hypertension, to meet the release pattern of Telmisartan tablets (IP) and Metoprolol succinate extended release tablets (USP). Formulation of Telmisartan part and formulation of Metoprolol part was carried out by wet granulation technique individually. Evaluation of granules such as angle of repose, loose bulk density and tapped bulk density, Carr’s compressibility index, Hausner’s ratio was carried out and the results were satisfactory. Evaluation of tablets like weight variation, thickness of tablets, hardness, friability, drug content, disintegration time, In-vitro dissolution studies, water content and moisture content was carried out. The results proved that the combination of this formulation immediate release and modified release bilayer tables of TL and ML will enhance the bioavailability of dosage regimen reduction and attenuation of drug administration for the effective antihypertensive therapy.