Histopathological Approach To Diagnosis &Classification Of Invasive Fungal Infections

Abstract

Background : IFIs are severe opportunistic diseases in many cases for immune compromised hosts and the threat is increasing due to the increase in the number of immunosuppressed patients. The histopathological examination is a critical aspect in the diagnosis and subsequent treatment of the disease and improvement of patients’ prognosis.

Objectives : To establish the usefulness of histopathological based techniques for the diagnosis and prognostication of invasive fungal infections in a group of patients.

Study design: A Cross-sectional biopsy analysis.

Place and duration of study. Department of Pathology Watim medical and dental college, rawat from jan 2021 to dec  2021

Methods : In this study, patients with suspected IFIs comprised of 150 patients. Biopsy specimens of the tissues were processed, and the sections made prepared by common histopathological methods, stained with PAS and GMS. The characteristics of fungal infiltrates were recorded, namely, the presence of the fungus, the type of fungal growth and the degree of fungal involvement.

Results : Out of 150 patients fungal elements were demonstrated in 85 cases. The positive case standard deviation was 8. 4; p-value = 0. 01, thus showing that there is a positive correlation between histopathological results and clinical assessment. The commonly isolated fungi were Aspergillus and Candi.

Conclusion : Histopathological evaluation of IFIs plays a major role in diagnosis and the classification of IFIs, which in relation to the immunosuppressive management of the disease has a substantial role in the management and treatment of the infections.