Study the Relationship between IL-17 rs 3748067 Gene Polymorphism with H. Pylori Infection in Babylon Province

Abstract

The objective of the current study is to prove a link between IL17 gene polymorphisms and H. pylori infection. We obtained Seventy-eight (78) cases with clinical symptoms associated with H. pylori infection. Two tests, fast Ab immunoassay and urea breath testing, located 45 patients with H. pylori infection. 45 individuals who appeared to be in good health were used as the control group, and their samples were taken. The urea breath test has been identified as the gold standard technique for non-invasive diagnosis. Additionally, ELISA, sequencing, and traditional PCR techniques were used to find the interleukin 17 gene. In patients compared to controls, the genotypes C/T and C/C were found to be more prevalent, with odd ratios (95% CI) of 2.75 (1.06-7.15) and 0.71 (0.22-2.36) and P = 0.05, respectively. This may suggest that these SNP variants are linked to greater H. pylori infection, in contrast to the T/T genotype, which showed no significant difference between patients and controls and may result in reduced H. pylori infection for carriers. With a mean concentration of 97.87 ± 39.56 pg/ml in the H. pylori infection group as opposed to 75.57 ± 22.75pg/ml in the control group, interleukin 17 levels were elevated. The results of the comparison between the level of IL-17 and the genotypes of the IL-17 gene revealed that the genotype C/T in IL-17 (rs 3748067) showed the highest concentration of IL-17 (119.79 pg/ml) in the serum of these studied groups, while the average serum level of C/C(78.65 pg/ml) and T/T groups (78.68pg/ml).