Effect of Bisphenol A Level in Follicular Fluid on ICSI OutCome

Abstract

Background: Infertility is the disability of a couple to obtain pregnancy after one year of sexual intercourse that is unprotected and regular. Bisphenol A (BPA) is an industrial chemical, that is produced in huge quantities worldwide. It is utilized as a raw material in multiple industries, and assorted as one of the endocrine-disrupting chemicals, as it can interfere with hormone activity. Bisphenol A may have a role in the reproduction process and may impact oocyte's maturity, meiotic division of germ cells, or fertilization rate. This study aimed to assess the impact of Bisphenol A level in follicular fluid on ICSI outcome.
Methodology: The study was conducted at the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies / Al Nahrain University, Baghdad /Iraq, at the interval extending from October 2021 to April 2022. Sixty infertile women enrolled in this study . BPA levels in follicular fluid were evaluated through an enzyme-linked immunosorbent assay (ELISA) technique.
Results: Of 60 patients enrolled in this study, 22 patients (36.3%) became pregnant. Bisphenol A was detected in follicular fluids (FF) of all patients. The mean follicular fluid BPA level was significantly lower in pregnant women in comparison with that of non-pregnant women (45.44±1.73 ng/ml versus 68.23±6.77 ng/ml, respectively P = 0.01). A significant positive correlation was detected between BPA levels in follicular fluid and Grade 3embryos (r=0.539, p=0.021).
Conclusion: Bisphenol A can be detected in follicular fluids of all patients undergoing IVF ̸ICSI. Elevated BPA levels in the follicular fluid may affect IVF̸ICSI outcomes (embryo quality and pregnancy rate)