Association of the Leptin Receptor Q223 (rs1137101) Polymorphism with Infertility in Iraqi Patient Women

Abstract

Obesity and Type2 diabetes mellitus regarded chronic metabolic disease and main causes of infertility in women. Obesity lead to increase of Leptin hormone level, A type I cytokine receptor called LEP-R serves as a receptor for the hormone leptin, which is only found in fat cells. The importance of this function is made clear by the leptin receptor deficiency condition, which is characterized by elevated leptin levels in the blood plasma and, as a result, by constant hunger and overeating that result in obesity and infertility. The LEPR gene, which is found in humans, encodes a protein that on 1p3.3. Ninety Iraqi women were enrolled as a samples in this study collected from women's hospital in Karbala city and teaching hospital and the women and children hospital of Al-Diwaniyah province from October 2020 to January 2021. Sixty infertility women were suffered from obesity and T2DM and 30 were apparently healthy considered as a control. Study data to analyze by chi square and odds ratio and p-value test used to detect significance of the means. Genotype result rs1137101 related with GG homozygous not associated with obesity compared with diabetes (16.66 versus 13.33%; X2 =0.131) and obesity compare with control (16.66 versus 30%; X2 =1.49). Result of rs1137101 related with AG heterozygous not associated with obesity compared with diabetes (73.33 versus 80%; X2 =0.373), and obesity compare with control (73.33 versus
60%; X2 =1.2). Result of rs1137101 related with AA homozygous not associated with obesity compared with control (10 versus 10 %; X2 =0), and diabetes compare with control (6.66 versus 10%; X2 =0.218). The result of this study concluded that rs1137101 revealed that GA heterozygous, GG and AA homozygous are not associated of incidence infertility that suffered from diabetes and obesity in Iraqi patient women.