Role of Serum Retinol Binding protein 4(RBP4) and it’s Various Correlations in Type 2 diabetes mellitus Population

Abstract

Diabetes mellitus is gaining the status of a potential epidemic and is the most common endocrine disorder, although major driving factors behind this epidemic are poor nutrition and lifestyle transitions, growing evidence supports a role of recently proposed adipokine i.e. Retinol binding protein 4 in the pathogenesis of type 2 diabetes mellitus Objective: To estimate serum RBP4 concentrations in type 2 diabetes mellitus patients and to correlate it with diabetic parameters like FPG, HbA1c, and BMI Methodology: 113 participants aged 35-55 years, both males and females were included, who were diagnosed and confirmed by the estimation of FPG (≥126mg/dl) and HbA1c level (≥6.5%) as type 2 diabetes mellitus patients. An equal number of age and sex-matched pre-confirmed non-diabetic individuals from hospital staff were recruited as controls. Serum RBP4 (Human) concentration was measured by quantitative sandwich enzyme-linked immunosorbent assay (ELISA) technology using Bioassay Technology Laboratory, ELISA kit Result: The concentration of serum RBP4 in the blood plasma of type 2 diabetes mellitus patients(76.53±26.96ng/ml) was found to be significantly higher than the healthy controls(53.77±12.62ng/ml), (P<0.001). Positive correlations were found between serum RBP4 with FPG, HbA1c, and BMI in the diabetic groups (p<0.001) Conclusion: The concentration of serum RBP4 was found to be increased in Type 2 diabetes mellitus patients, and related to various clinical parameters of diabetes, suggesting a role in the pathogenesis of Type 2 diabetes mellitus.