CORRELATION OF RECURRENT APHTHOUS STOMATITIS WITH HAEMATOLOGIC (IRON, FOLIC ACID AND B12) DEFICIENCIES

Abstract

Context: Recurrent Aphthous Stomatitis is among the most common oral disorders. The present study attempts to evaluate the causative factors of RAS.
Aim and Objective: The objective of the study is to analyse the role of deficiency of serum iron, serum folic acid and serum vitamin B12 occur in subjects affected by RAS and its comparison with healthy subjects.
Materials and Methods: The present study was a clinical comparative study with two groups – study group (n = 50) and control group (n = 50),. The serum levels of iron, folic acid and vitamin B12 was measured in venous blood on both study and control groups.
Result:‘t test showed a significant difference in serum levels of Vitamin B 12, folic acid, and iron between males and females in control and study groups respectively. A significant difference was also observed in serum iron and vitamin B12 between males and females (control groups) only i.e. P < 0. 01. Results established a significantly positive relationship ratio in between the occurrence of RAS and deficiency of vitamin B12 in the serum of affected subjects.
Conclusion: Present study concluded that vitamin B12 and folic acid deficiency may be an important factors in the establishment of etiopathogenesis of RAS. But further research is needed for a wider spectrum with a broader age group and a large population.