Evaluation of the Effect of Ciprofloxacin on some Cytokines in Mice

Abstract

The purpose of this study is to see if therapy with Ciprofloxacin (80 mg/kg body weight) for 3, 7, or 14 days has any influence on the levels of (Cytokines - 2, 4, 6, 10) in albino mice. The albino mice were put into four equal groups for the investigation. G. I: - The animals in this group were not given any material (control). G. II: - The animals in this group were given ciprofloxacin (80 mg/100 g body weight) (Dosage one per day Orally) for three days. G. III: - The animals in this group were given ciprofloxacin (80 mg/100 g body weight) (Dosage one per day Orally) for seven days. G. IV: - For 14 days, animals in this group were given ciprofloxacin (80 mg/100 g body weight) (Dosage one per day Orally). The results show that ciprofloxacin greatly increased Cytokines - 10 (especially after 14 days of therapy) (p<0.01), as well as Cytokines - 2, 6 (p<0.01), whereas Cytokines - 4 greatly decreased (P<0.05).