Effectiveness Of Glimepiride And Glimepiride + Vitamin-C In Type-2 Diabetes Mellitus Patients Associated With SOD2 Gene Polymorphism

Abstract

Introduction: Diabetes mellitus (DM) is characterized by hyperglycemia, usually associated with the rise in oxidative stress. Oxidative stress plays a major role in diabetes and its complications. Methods: 40 newly diagnosed type-II DM patients were recruited after measuring glycolated hemoglobin (HbA1c), fasting blood sugar (FBS) & postprandial blood sugar (PPBS) & malondialdehyde (MDA) & total antioxidant capacity (TAC). Genetic test was done for detecting SOD2gene polymorphism (Superoxide dismutase). Patients were divided into two groups, group-A (n=20) &B (n=20). Group–A patients were given Glimepiride (1mg) and group-B patients were given Glimepiride (1mg) + vitamin C (1000 mg) OD for 3 months. After the commencement of the study glycemic level and oxidative stress were measured and compared with basal values. Results: 3 genotypes were identified, such as CC, CT and TT. After 3 months of study, there was a significant reduction in mean HbA1c, FBS and PPBS (p<0.05) in all genotypes of both group-A& B, but overall the mean reduction was more in CC genotype followed by CT and then TT genotype. Oxidative stress was reduced significantly in the CC and CT genotype (p<0.05) but not in the TT genotype of the group–B, whereas group-A (all 3 genotypes) had shown elevation of oxidative stress. Conclusion: Vitamin C supplementation have better control over the glycemic level and oxidative stress.