Periodontal Gel For The Targeted Drug Delivery In The Periodontal Cavity For Management Of Periodontitis And Gingivitis

Abstract

When medications are taken orally or through another route into the systemic circulation, their blood concentration steadily rises and
peaks (C max) after a few hours. Based on the medication's physicochemical makeup, the drug's pharmacokinetics (ADME). A
maintenance dose must be given when the medication level is expected to be reduced or close to the efficacy threshold after achieving
the peak plasma concentration (C max) in blood [1]. We can now distribute medications to the systemic circulation in a controlled and
precise manner for longer pharmacological action, minimize the frequency of dose and unpleasant effects, improve patient compliance,
and give the desired impact. Since several processes occur after a medication is administered at the application site and before it reaches
the target location in CDDS, its concentration in the blood is frequently affected by metabolism and excretion, making it difficult to
notice the desired impact. This issue can be solved by injecting the medications right into the affected area, allowing a lower dose to
produce the desired effect. Local drug delivery systems are more effective since they are less expensive, more stable, less toxic,
biocompatible, and biodegradable. The proper management of a patient with periodontitis and gingivitis, the utilization of periodontal
pockets as a site for the application of medication, the design of an appropriate dose form, and its potential benefits are the main topics
of this review. A unique technique for treating diseases like periodontitis and gingivitis could be useful in a more effective treatment
since the microorganisms in periodontal pockets could seriously destroy periodontal tissues.