Association Of Klotho Gene With The Renal Stone Disease- A Meta-Analysis

Abstract

Introduction: Nephrolithiasis is a multifactorial disease. Genetic polymorphisms have been proposed as risk factors for kidney stone incidence and recurrence. The Klotho gene is one of the important proteins involved in calcium homeostases such as para thyroid gland, kidney, and the epithelium of the choroid plexus in the brain.
Objectives: To assess the association of G395A Single Nucleotide polymorphisms (SNPs) of the klotho gene with renal stone disease.
Materials and methods: PubMed, and Google scholar were searched between November 2020 and April 2021 to identify eligible studies with the keywords G395A, klotho, polymorphism, and Nephrolithiasis or renal calculi. Total of three articles were included in the study. Random effect models as well as fixed effect models were used to find out the association of G395A SNP with kidney stone patients. Forest plot as well as funnel plot is plotted to assess the heterogeneity and publication bias respectively.
Results: The present study results were carried out using medcalc. Our pooled calculation found that GG genotype has more risk effect against kidney stone disease with OR of 2.383 with a 95% confidence interval of 1.700 to 3.340 , p<0.001. No publication bias was observed.
Conclusion: GG genotype of G395A SNP are significantly associated with the risk of kidney stone disease. However, the GA & AA genotype of Klotho gene G395A were not associated with the kidney stone disease.