SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND ANTICANCER EVALUATION 2-AZETIDINONE DERIVATIVES CLUBBED WITH THIAZOLE

Abstract

A series of thiazole conjugated 2-azetidinones (1-20) was designed and synthesized. All synthesized derivative were evaluated for their antiproliferative potential against Hela cancer cell lines and antimicrobial activity respectively. Compounds 9 (IC₅₀ = 58.86 µM) was found to be most potent anticancer agent. None of the substances was more effective than standard Doxorubicin. In case of antimicrobial activity, compounds exhibited good antimicrobial activity in comparison with standard drugs.