Synthesis, Physicochemical And Spectral Characterization Of Novel Cannabidiol Derivatives As Anti-Epileptic Agents

Abstract

Epilepsy is the second most common chronic neurological condition characterized by recurrent seizures affecting more than 60 million
people world-wide. Since currently available antiepileptic drugs have been associated with several side effects and fail to control
seizures in about 30% of epileptic patients, there is a substantial need for development of new, more effective and less toxic antiepileptic drugs. The present study aim to generate pharmacophore and to design the structure of lead molecule from which a series of analogues of the lead molecule is to be synthesized and screen them for anticonvulsant activity. Preliminary anticonvulsant evaluation of all the newly synthesized cannabidiol derivative of heterocyclic compounds were done against seizure models, Chemical test subcutaneous pentylenetetrazole (scPTZ). Synthesized compounds were characterized by spectral analysis (FT-IR, 1 H-NMR). In the present series of compounds, cannabidiol derivatives were designed and synthesized to meet structural requirements essential for anticonvulsant activity. The anticonvulsant data revealed that newly synthesized compounds Compound-1, Compound-4, Compound-10, Compound12, afforded significant protection at 10mg/kg; i.p. in sc PTZ test. The anticonvulsant activity of the other tested compounds was found to be much moderately effective then phenytoin used as standard anticonvulsant