PLATELET RICH DERIVATIVES FOR ACCELERATION OF ORTHODONTIC TOOTH MOVEMENT: A SYSTEMATIC REVIEW OF RCTS.

Abstract

BACKGROUND: Platelets Rich Plasma (PRP) therapy has been in use for periodontal healing  as it speeds up the process thereby reducing time also injection of high concentration PRP could accelerate orthodontic tooth movement via decreasing alveolar bone volume density on paradental tissues in a transient way.

AIM: The aim of this review is to systematically report and appraise the current evidence on the effectiveness of platelet rich derivatives in accelerating orthodontic tooth movement.

MATERIALS AND METHODS: The reporting of this systematic review was according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement. Detailed search strategies were prepared and 3 electronic databases were searched for the eligibility criteria.The Cochrane Collaboration’s Risk of Bias tool was used for qualitative assessment of the included studies.

RESULTS: 4 studies satisfying the selection criteria were included. All of the 4 studies reported significant acceleration of tooth movement with  platelet rich derivatives.1 study reported high risk of bias and 3 studies reported unclear risk of bias.

CONCLUSION: The available literature suggests acceleration of tooth movement with plasma rich derivatives but the quality of evidence is moderate to low and hence more high quality RCTs are needed.