Anthelmintic Activity And Insilico Study Of Phytoconstituents In Mirabilis Jalapa Root Extract

Abstract

Traditional system of medicine is devoid by hazardous impacts on health, and it will be safer which ensures the healthy lifestyle. Several effective medicines were used in their natural state as therapeutic agents in different parts of the world, based on empirical study of their application.

The revolution aspect in industry has made a second generation of plant drugs emerged based on scientific processing of the plant extracts to isolate ″their active constituents″. Plant materials remain an important component in combating serious diseases in the world, for the therapeutic approach to several pathologies. Interest in medicinal plants has been overwhelming in the recent times especially as an important source of medication/health care. By 2000, World Health Organization had assessed that 80% of inhabitants of the world were estimated who were only relies on traditional medicines for the needs of primary health care and it also presumed that the major portion of traditional healing involves by utilizing the extracts or active constituents of plants ¹.

By 2003, Indian Council of Medical Research estimated that the global market for medicinal plants has been around US $62 billion, and the demand is growing rapidly even still². The goals of using plants as sources of therapeutic agents were to isolate bioactive compounds for direct use as drugs, to produce bioactive compounds of novel or known structures as lead compounds, to use agents as pharmacologic tools, to use the whole plant or part of it as a herbal remedy³.

The use of herbal medicine for the treatment of diseases and infections is as old as mankind. Indian medicinal plants also provide a rich source for oxidants that are known to prevent delay different diseased states. The antioxidant protection is observed at different levels. Medicinal plants have been used since time immemorial for treatment of various elements of skin and dermatological disorders especially cuts, wounds, and burns. The world health organization estimated that 80% of people worldwide rely on herbal medicines for some aspect of their primary health care.

According to World Health Organization (WHO); traditional, complementary, alternative, or non-conventional medicines are used by 70-95% of global population particularly in developing countries for their healthcare⁴. Moreover, the use of herbal medicines has increased remarkably in line with the global trend of people returning to natural therapies⁵. The growing use of botanicals (drug and other products derived from plants) by the public is forcing moves to assess the health claims of these agents and to develop standards of quality and manufacture.

The Indian system of medicine, mainly comprising of Ayurveda, Siddha and Unani, is one of the oldest holistic management systems with thoroughly documented remedies. Ayurveda, a part of cultural heritage of India, is widely respected for its uniqueness and global acceptance as it offers natural ways to treat diseases and promote healthcare⁶.

India can emerge as a major country and play the lead role in production of standardized, therapeutically    effective    Ayurveda formulations.   India needs to explore the medicinally important plants, and this can be achieved only if the herbal products are evaluated and analyzed using sophisticated modern techniques of standardization. Liver disorders are considered among the major world health problems⁷. A single herbal drug extract was standardized on the basis of its active principles. As per literature review, only very few chemical or analytical methods are available for herbal drug standardization⁸.