Sex Hormone Binding Globulin (SHBG) - A Potential Biomarker for Insulin Resistance, Non-Alcoholic Fatty Liver and Hepatic Lipogenesis

Abstract

The liver produces and secretes sex hormone-binding globulin (SHBG), which binds to sex steroids and controls their bioavailability in the bloodstream. Recent research indicates that, insulin resistance, liver fat content, hepatic lipogenesis is a significant predictor of circulating SHBG. In this review we discuss the role of SHBG as a potential biomarker that may lead to new diagnostic and therapeutic methods.