IMPACT OF DIABETES MELLITUS, INSULIN RESISTANCE AND OBESITY IN ALCOHOLIC LIVER CIRRHOSIS

Abstract

Background: A leading cause of chronic liver disease and liver failure, with increased morbidity and mortality, diabetes mellitus, obesity and insulin resistance are ubiquitous in Alcoholic liver disease patients and increase the risk of liver-related frailty. The prevalence of risk factors like diabetes mellitus, insulin resistance and obesity in alcoholic liver cirrhosis and to analyse the clinical profile and severity of alcoholic liver cirrhosis within these risk factors either alone or in combinations were the objective of our study.

Methods: An observational study with 107 patients and onset of liver disease, anthropometric examination, clinical examination and laboratory data were recorded. Diabetes mellitus was diagnosed by WHO criteria of fasting, postprandial blood glucose and HbA1C levels. Obesity was diagnosed in patients with BMI >25 kg/m². IR diagnosis is as per HOMA-IR score. Results: The male predominace was higher in alcoholic liver cirrhosis. Mean age was 48.3 ± 10.03 years; age group between 40-49 years had 40.19% of study population. Most common symptom was abdomen distension (57.94%) followed by leg swelling (55.14%) and jaundice (54.21%). The mean alcohol duration was 18.69 years. The mean alcohol consumption was 130.7 ± 53.62 gm/day. Relationship between Alcoholic liver cirrhosis and diabetes mellitus, IR and Obesity when compared with CTP score had P value 0.743, 0.170 and 0.500 respectively, MELD score had P-value 0.967, 0.649 and 0.324 respectively. Conclusion: Alcohol duration and consumption increases the severity of alcohol liver cirrhosis. Impact of Diabetes Mellitus, IR and Obesity in alcohol liver cirrhosis was no significant.