COMPARATIVE STUDY OF CALCIUM DOBESILATE VERSUS PLACEBO IN CHRONIC VENOUS INSUFFICIENCY

Abstract

Introduction: Chronic venous insufficiency (CVI) is the inability of veins to transport blood unidirectionally to the heart with flow consistent with tissue drainage, thermoregulatory and hemodynamic reserve needs, regardless of venous location or activity. Many randomized clinical trials (RCTs) have shown beneficial effects of calcium dobesilate.

Aims and Objective: Objective of the study was to compare the efficacy and effectiveness of calcium dobesilate versus placebo for chronic venous insufficiency.

Material and Methods: This present study was carried out in the Department of Surgery, Muzaffarnagar Medical College, Muzaffarnagar, UP, India from March 2020 to March 2022.

Results: A total of 150 subjects were enrolled in this study. 75 subjects were taken Calcium Dobesilate drug (500mg) twice a day for 08 weeks and 75 were taken Placebo Drug. The symptoms of pain, discomfort, heavy legs, tired legs, tingling, itching and cramps, as well as the global assessments by investigators and patients, also improved significantly (P < 0.05) better in the dobesilate group at the end of the treatment.

Conclusion: Calcium Dobesilate improves the symptoms of objectively diagnosed CVI, independent of the concomitant usage of compression stockings.