Review of Polymeric Nanomicelles

Abstract

It is estimated that 90% of new drugs in development are classified as poorly soluble. Many drug molecules are lipophilic or hydrophobic in nature and thus they usually show low bioavailability, poor absorption properties, low permeation as well as inability to reach an effective therapeutic concentration in blood. To overcome this problem, nano micelles are the breakthrough drug delivery system in which a lipophilic drug can be incorporated into polymeric micelles or surfactant micelles that can provide high solubility as well as high bioavailability. Since Micelles have an inner lipophilic core and outer hydrophilic shell as well as the inner lipophilic core provides space for incorporation of the lipophilic drug, it enhances the permeability of the lipophilic drug even at depth and also at the target site. The present review outline various applications of nanomicelles, their advantages as well as limitations, methods of preparations, and various approaches for applications of nanomicelles.