EFFECT OF BREADFRUIT LEAF EXTRACT (ARTOCARPUS ALTILIS) ON CHANGES IN SGPT AND SGOT LEVELS TYPE 2 DIABETES MELLITUS PATIENTS

Abstract

Type 2 Diabetes Mellitus (T2DM) is chronic hyperglycemia due to insulin resistance where there is an accumulation of intracellular glycogen in hepatocytes which causes an increase in glycogen synthesis. Supplementing natural ingredients with hepatoprotective and anti-free radical activity can neutralize ROS increase and regenerate pancreatic cells damaged by T2DM. This study aims to analyze the effect of breadfruit leaf extract on SPGT and SGOT levels in T2DM patients, as many as 39 research samples aged 36-65 years. Through experimental research with randomized controlled trial pre and post-test, this study found that there was a significant difference (p = 0.02) in respondents' SGOT levels between the control group and the intervention group who were given breadfruit leaf extract (decreased to 1.31 grams), yet there was no significant difference in respondents' SGPT levels between those groups (p=0.121). This study also found the importance of monitoring and evaluating medication adherence for T2DM patients.