The CRISPR-Cas System: How It Works In Bacteria And How It Can Be Used To Encounter Antimicrobial Resistant Pathogens

Abstract

The proliferation of bacteria that are resistant to antibiotic therapy presents a significant threat to public health. In lieu of the progress that has been made in antimicrobial therapy, the frequency of chronic conditions triggered by microorganisms that are resistant to such treatments is on the ascent. As a result, researchers are being forced to come up with new strategies to combat the issue. The CRISPR-Cas system, which has become increasingly popular in recent years, has been put to use to combat antimicrobial resistance in both exterior and interior pathogens. In this review, we focus on several of the application of the whole system and an option to combat the antimicrobial resistance in bacteria.  We discuss a recently developed method known as a Nano-sized CRISPR system, which was used to address the genetic mutation without the assistance of a bacteriophage. The change in bacteria that are resistant to antimicrobial treatments makes it more challenging to put similar strategies into practice in the real world.