MID: a specific database and online platform for male infertility

Abstract

In developing countries, especially like India and China, people have a strong mindset and fully emphasis on
child-bearing. Currently, human male infertility percentage is increasing drastically. Infertility is not a disease and
it is treated as a condition with physiological, medical implications. Diagnosis of idiopathic males is difficult than
any other category and it is very hard to find out the reasons for infertility. There are no existing databases to
study easily about the various genes associated with male infertility. To elucidate the basic knowledge about
semen and its composition, various causes, microelements and its role, treatments and genetic causes, as well as
to retrieve the basics about the genes and proteins involved with male infertility. MID (Male Infertility Database)
was implemented as a web interface using PHP scripting language at backend and HTML, CSS & JavaScript
(jQuery Framework) were used at the frontend/client side. The data were collected from the bioinformatics
common database like PDB, UniProt and Entrez databases. These data were appropriately filtered using
specialized systematic literature and our previous knowledge on male infertility. The current information about
male infertility and updated literature were retrieved from Science direct, Science alert, Goggle Scholar, PubMed
and PubMed central. MID provides three modules (“Search”, “Browse” and “Statistics”) that enable searches,
acquisition of contents and access to all updated statistical data. The direct links to matching external databases
are also available. The database will be updated at interval corresponding to genes and protein related to male
infertility. The compilation of all general information, sequence and structural data of all genes and protein in one
platform is highly useful for current experts and budding researchers in human reproduction and male infertility
area.