Ethanolic Extract of Moringa oleifera Leaves Ameliorates TNF- and IL-8 Level from Rat Model of S. Aureus-Induced Rhinosinusitis

Abstract

Background: Acute bacterial rhinosinusitis is a common complication that require antibiotic therapy to recover promptly. To avoid the
emergence and spread of antibiotic-resistant bacteria, Ethanol extract of moringa leaves (EEMO) contains active ingredients that serve as
antioxidants that can help restore redox metabolic balance and can reduce excess free radicals so as to prevent oxidative stress and speed
healing.
Materials and Method: Effect of moringa leaves ethanol was evaluated in difference day post treatment, day 7th and day 10th. The level of
TNF-a and IL-8 from each treatment group in Staphylococcus aureus rhinosinusitis induced rat was evaluated using ELISA compared to
control group. Data were analyzed using SPSS 25.0 for Windows.
Result: The results of the analysis of different tests of paired T-Test can be concluded that there is decrease in the average level of TNF-α
and IL-8 on the 7th day with the 10th day in the T2, T3 and T4 groups there is significant difference (p = 0.0001), while the T3 group has
the most decrease TNF-α and IL-8 serum level (p = 0.0001).
Conclusion: The combination of Amoxicillin 27 mg/day and EEMO 100 mg/kg is better at decreasing both TNF-α and IL-8 levels during 10
days of administration. EEMO can be used as an adjuvant therapy for acute bacterial rhinosinusitis.