Absence of hypolipidemic effect of Holoptelea integrifolia leaf extract in tyloxapol-induced hyperlipidemic rats

Abstract

Objective: The leaves of Holoptelea integrifolia are used in the treatment of diabetes and
lipid disorders. The present study demonstrates the influence of the aqueous extract of
leaves of Holoptelea integrifolia (HIAE) on the lipid profile in normal and Tyloxapolinduced hyperlipidemic rats. Materials and Methods: The vehicle, the aqueous extract
of leaves of Holoptelea integrifolia (250 and 500 mg / kg), and fenofibrate, reference
standard (65 mg / kg), were administered orally for seven days to different groups of
normal and Tyloxapol-induced hyperlipidemic rats. The lipid profile was assessed on
the eighthday by estimating the plasma levels of total cholesterol, triglycerides, HDL-c,
LDL-c, VLDL-c, and the corresponding atherogenic index and the LDL-c/HDL-c
ratio. Results: Administration of the HIAE neither caused any significant effect on the
lipid profile in normolipidemic rats nor attenuated tyloxapol-induced hyperlipidemia.
Conclusion: The present investigations revealed that the aqueous extract of the leaves
of Holoptelea integrifolia did not exhibit a hypolipidemic effect and did not substantiate
its traditional use in lipid disorders and obesity.