A Comparative Study Of Oral Pregabalin And Oral Pregabalin With Intravenous Fentanyl For Attenuation Of Pressor Response To Tracheal Intubation And Laryngoscopy – A Randomised Double Blind Study

Abstract

Cardiovascular response to air way instrumentation is a hazardous complication of general anaesthesia. It is associated with hypertension and tachycardia which is transient and often an unwanted body response. These variations are usually well tolerated in normal patients who are devoid of cardiac disorder or altered intracranial pressure. The stimulation of upper respiratory tract both during laryngoscopy and tracheal intubation leads to intense sympathetic discharge as seen by rise in catecholamine levels, hence causing the pressor response.

Haemodynamic response is exaggerated in hypertensive patients even though they may be normotensive pre-operatively by antihypertensive drugs. This response may lead to intra- perative myocardial infarction, acute left ventricular failure and intracranial bleed in patients with end organ decompensation.