Formulation And Characterization Of Chitosan Based Mucoadhesive Microspheres For Treatment Of Intestinal Infection

Abstract

The mucoadhesive properties of chitosan microspheres prepared by different method were evaluated by studying the interaction between mucin and microspheres at targeted site. The aim of this study was to investigate the capabilities of chitosan microspheres as drug carrier system to improve the site specific drug delivery via mucoadhesion approach. Different formulations were developed and morphological studies of the optimized formulas showed that the size range of spherical shaped particulate matters. It was planned to develop naturally occurring biodegradable polymer based colon- targeted drug delivery systems of selected drug or drug combination for the prevention of intestinal round worm. Such site-specific drug delivery systems are expected to provide majority of their drug load to colon without being released in stomach and small intestine. As a result, it may be possible to provide an effective and safe therapy for the prevention of intestinal infection with a lower dose of drug. The in vivo mucoadhesive study was further selected by the radiological technique for justified the increased residency time in the stomach. Thus chitosan microspheres appear, technically, promising mucoadhesive drug delivery systems for delivering metronidazole to treatment stomach worms at site specific intestine.