Synthesis And Characterization Of Hydrazide Based 1,3-Benzoxazole Derivatives As Antitubercular Agents

Abstract

INTRODUCTION

Tuberculosis (TB) is one of the most common, communicable, and fatal diseases known to mankind. Tuberculosis is one of the world’s great public health threats due to resistance to existing drugs. It is potentially serious infectious bacterial disease that mainly affects the lungs. The mycobacterium tuberculosis usually attack the lungs, but they can also damage other parts of the body. TB is spread through the air when a person with TB of lungs or throat coughs, sneezes, or talks.

MATERIALS AND METHODS

To Synthesize the hydrazide based Benzoxazole derivatives as Antitubercular agents and Study their biological activity along with structural assessment by using the various techniques of structural elucidation. All chemicals required for the synthesis were procured from Lobachem Laboratories, all chemical are synthetic grade.

REUSLT AND DISCUSSION

All the above compounds synthesized from 2-phenyl benzoxazole -5 carboxylic acid hydrazide with the reactive carboxylic group , acetophenone analogs to forming cyclization followed by peptide bond . In the synthetic pathway, during synthesis of intermediate 2 i.e, reduction of nitro group into amino group done by sodium dithionite this reaction was optimized by using various reducing agents like Zn/HCL, stannous chloride, copper sulphate and sodium borohydride but there is no desired product obtained. The purity of all synthesized compounds were confirmed by melting point and thin layer chromatography

CONCLUSION

The dissertation is concluded that the synthesized molecules are effective in inhibiting the mycolic acid cyclopropane synthase (cmaA1) which is play important role in mycolicbacterial cell wall growth. All compounds are showing the significant effect on target enzyme.