Absence of central activity in Wrightia tinctoria bark ethanolic extract

Abstract

Objective: The objective of the present study was to investigate the central activity
profile of Wrightia tinctoria (Roxb) R.Br. Linn. (Family: Apocynaceae) in mice and rats
using various models. Materials and Methods: The effects of ethanolic extract were
observed in 3 different dose levels 300, 500, and 1000 mg/kg as the extract did not
show any signs of toxicity up to 5000 mg/kg (p.o.) dose. Investigations were carried out
for assessing the activity on pentobarbitone-induced hypnosis and maximum electroshock (MES)- and leptazole-induced convulsions. Results: W. tinctoria ethanolic extract
did not have any significant effect on pentobarbitone-induced hypnosis. The extract is
devoid of any protective effect against leptazole- or MES-induced convulsions at any of
the tested doses. Conclusion: W. tinctoria bark ethanolic extract had no central nervous
system depressant or anticonvulsant activity