Estimation Of Interleukin 27 And Interleukin 33 Serum Levels In Iraqi Neonatal Sepsis

Abstract

Bloodstream infections in neonates are one of the most life-threatening infections in them . In this study, a total of 140 blood samples were
collected from neonates at AL-Batoul Teaching Hospital for Gynecology and Pediatrics in Baqubah/Diyala, their ages ranging from 1 day
to 28 days during the period from November 2021 to March 2022. The samples were subjected to a culture study as well as hematological
and immunological tests (CRP, measuring the level of IL-27 and IL-33). Out of total cultured samples 45 give a positive blood culture, 45
specimens from blood culture negative was chosen to become (control group) to be comparable to positive culture specimens. The results
of the CRP test showed in the Gram-negative bacteria group, the positive result was 76.92% (10 of 13). In the Gram-positive bacteria group,
the positive CRP percentage was 84.85% (28 of 33). While in the control group the positive result was 13.33% (6 of 45) , significant
differences appeared between the compared groups. The results showed the mean levels of IL-27 in the sepsis patient group and control
group were (21.14 ± 1.01 and 14.49 ± 0.34 pg/ml, respectively). also showed the mean levels of IL-33 were in the sepsis patient group and
control group (250.28 ± 15.75 and 101.16 ± 3.38 pg/ml, respectively). There was a significant increased level of IL-27 and IL-33 in the sepsis
patients’ group compared to the control group.