Study Of Coinfection Of Viral Hepatitis C And Hiv-Infection In Uzbekistan

Abstract

The aim of this study is to determine the role of IL28B gene polymorphism in the prognosis of fibrosis development. The object of the study were 120 patients with liver cirrhosis of the class. And according to Child-Pugh HCV etiology and 110 patients with coinfection (CHC and HIV). It has been proven for the first time that the IL28B gene polymorphism is the leading a marker of the risk of progression and formation of cirrhosis of the liver of class A according to Child-Pugh HCV etiology in HIV-infected patients. It has been proven for the first time that the non-CC genotype of the rs12979860 polymorphism in HIV-infected patients with HCV Child-Pugh A cirrhosis etiology is the reason for the acceleration of the process of fibrosis in the liver. Liver on the example of patients with coinfection (CVHC+HIV infection).