Method Of The Development And Validation For The Determination Of Atorvastatin In Both Bulk And Commercially Pharmaceutical Products

Abstract

A new method was developed and validated utilizing Nanodrop 2000 spectrophotometric for the measurement of Atorvastatin calcium trihydrate (ACT) in both bulk and tablet dosage forms. Atorvastatin's highest absorption was observed at 243 nm using Methanol as a solvent. The developed method was discovered to be linear (R2 = 0.9997) between 5 and 25 μg/mL in terms of concentration. Acceptable RSD% values (less than 0.5%) are provided by the precision and accuracy research. The results showed that the LOD and LOQ were, respectively, 0.446 and 1.488 μg/mL. The essay analysis revealed excellent recovery at around 98% for drug products in commercial tablets. It can be concluded that the present method is acceptable according to the International Conference on Harmonization (ICH) guidelines for drugs.