Lack of analgesic property in xanthium strumarium Linn. Fruit’s butanolic extracts

Abstract

Objective: The objective of the present study is to investigate the analgesic activity
profile of xanthium strumarium Linn. (Family: Asteraceae) in mice and rats, using various
models. Materials and Methods: The effects of the butanolic extract were observed
in three different dose levels 50, 100, and 150 mg / kg, as the extract did not show
any sign of toxicity up to 500 mg / kg (p.o.) dose. The investigation was carried out
for assessing the activity on thermal and chemical-induced pain reactions. Result: The
Xanthium strumarium (XS) fruit’s butanolic extract did not have any significant effect on
the thermal pain reaction (hot plate method). The extract was devoid of any protective
effect against acetic acid-induced writhing, at any of the tested doses. Conclusion: The
Xanthium strumarium Fruits’ butanolic extract lacked analgesic activity