TO COMPARE THE EFFICACY OF 0.1% TACROLIMUS VERSUS MOMETASONE FURATE TOPICAL TREATMENT OF ALLERGIC CONTACT HAND ECZEMA

Abstract

Objective: To compare the efficacy of 0.1% tacrolimus versus mometasone furate topical treatment of allergic contact hand eczema.

Materials and Methods: Study design was Randomized Controlled Trial.

Setting: Department of Dermatology, Pakistan Institute of Medical Sciences, Islamabad.

Duration of study: 6 months after approval of synopsis i.e 30^th Oct, 2019 to 30^th April, 2020.

Data Collection Procedure:  After taking approval from hospital ethical committee, 150 patients meeting inclusion criteria were included in this study through OPD of Department of Dermatology, Pakistan Institute of Medical Sciences, Islamabad. In group A, mometasone furoate 0.1% ointment were prescribed. In group B, tacrolimus 0.1% ointment were prescribed. After 8 weeks, patients were re-evaluated and if there were 75% clearance of eczema lesions, then efficacy were labeled. All the information was gathered through proforma.

Results: Total 150 patients were included according to the inclusion criteria of the study. Patients were randomly divided into two groups. Patients in group A were prescribed by mometasone furoate while patients in group B were prescribed by 0.1% tacrolimus. Mean age (years) in the study was 49.99+15.52 whereas there were 62 (41.3) male and 88 (58.7) female patients who were included in the study according to the inclusion criteria. Frequency and percentage of efficacy of mometasone furate versus 0.1% tacrolimus topical treatment of allergic contact hand eczema was 18 (24.0) and 63 (84.0) which was statistically significant (p -value 0.000).

Conclusion: The study concluded that tacrolimus was more effective than mometasone furate for treatment of hand eczema. Future studies at multiple setups must be conduct in order to know the local evidence of efficacy among both the protocols in order to know the implement of practice of more effective drug for better management of patients with hand eczema.