Effect Of Aqueous Alcoholic Extract Of Devil’s Claw On The Serum Levels Of Adiponectin, Agouti, Omentin, Amylin, Orexin A, Resistin, Chemerin, Ghrelin, Leptin, NPY, And Epinephrine In Weight Changes In Rats

Abstract

Background: Nowadays, obesity and its complications are considered a serious human society’s problem, due to which it seems necessary to find the best ways to lose weight. Nowadays, herbal compounds, due to fewer side effects, more availability, and less toxicity get more attention. The present study aims to investigate the effect of Aqueous alcoholic extract of devil’s claw on the serum levels of obesity-related-peptides such as adiponectin, agouti, omentin, amylin, orexin A, resistin, chemerin, ghrelin, leptin, NPY, and epinephrine in weight changes in rats.

Method and materials: Forty adult male Wistar rats (180- 200 grams) were used. Then the rats were divided into five groups: control (no treatment), sham (1 ml of distilled water), and devil’s claw groups with concentrations of 150, 300, and 600 mg/kg (by gavage/ n=8/ 28 day). On the 29th day, animals were weighted and blood samples were taken. ELISA kit was used to measure the serum concentrations of obesity-related-peptides.

Results: Devil's claw extract reduces food intake by lowering orexin, resistin, and chemerin, which increase in obesity, and raising adipokines that cause weight adjustment and reduction of food intakes such as adiponectin, ghrelin, norepinephrine, omentin, and amylin in a dose-dependent manner.

Conclusion:  This study revealed that devil’s claw extract has anti-obesity effects, especially at higher doses. These findings suggest that devil’s claw reduces NPY and rises leptin, thereby preventing appetite. This herb has anti-inflammatory and antioxidant effects, alters adiponectins secretion, causes weight loss, and reduce the lipid profile; examining the details of these signaling is recommended.