Correlation Of Smoking And The Level Of Icam-1 And Vcam-1 Serum As A Criterion Of Buerger’s Disease

Abstract

Background and Aim: Obliterative thromboangitis (TAO) or Buerger's disease is an inflammatory obstructive disorder that affects the vascular organs of young smokers. The immune system appears to play a major role in the etiology of TAO. However, information on aspects related to the evolution of vascular inflammation and the disease is still limited.

Objective: This study was performed to evaluate the concentration of (ICAM-1, VCAM-1) in smokers and non- smokers.

Methods: 108 samples of this study consisted of two groups of smokers and non-smokers. Blood samples of non- smokers were collected from non-smokers who donated blood in Mashhad Blood Transfusion Center and blood samples of smokers were collected from Mashhad University of Medical Sciences, Imam Reza Hospital. Through a comprehensive questionnaire, we extracted information about each individual completed by the individual. In this study, 108 people, 57 smokers and 51 non-smokers, were studied. The mean age of smokers and non-smokers was

49.67 ± 8.91 and 48.08 ± 7 7.7 respectively. The number and mean age of participants in this study in two groups of smokers and non-smokers, the concentration of ICAM-1 and VCAM-1 measured were by ELISA kit method to determine the levels of these markers in two groups. The results of this study were analyzed using SPSS 26 statistical software and using Chi-square (2χ), t-test and Mann-Whitney test (for abnormal data) with a significance level of P

<0.05.

Results: The smokers participating in this study are 45 people with an average of 0.13± 0.17. Also, 45 non-smokers with an average of 0.16 ± 0.12 form the control group. As the results show (Z = 2.15, P = 0.031), the amount of ICAM-1 in the non-smoking group is higher than the smoking group. The smokers participating in this study were 45 with a mean of 0.81± 0.36. Also, 45 non-smokers with an average of 0.74± 0.26 constitute the control group. As the results show (Z = 0.024, P = 0.981), there is no significant difference between the mean of VCAM-1 in the non-smoking and smoking groups.

Conclusion: ICAM-1 as a potential target for diagnosing the immune response against tobacco and its association with vascular diseases such as Burger disease.