The Clinical, Polysomnographic And Biological Aspects Of Insomnia In Male Patients With Opioid Use Disorder

Abstract

Background Substance use and misuse are serious issues that contribute to significant medical, psychological, and legal consequences later in life. Additionally, the relation between substance use disorder and sleep is reciprocal. Furthermore, sleep dysfunction in the context of substance use disorder may contribute to increased severity of substance use disorder and increased risk of relapse Aim and objectives to investigate patients with opioid use disorder comorbid with insomnia and assess their clinical and biological aspects of insomnia, cognitive function, and serum level of BDNF in comparison to those without substance use disorder. Subjects and methods This is a cross sectional comparative study. Cases were recruited from inpatient section and outpatient clinic in Psychiatry Department in Mansoura University Hospital. The research was done for one year from January 2021 to January 2022. Result shows that patients in heroin group show statistically significant (p=0.039) lower total sleep time (240.04±54.8) than control (275.2±48.9). They show also, statistically significant (p=0.027) longer sleep onset in comparison to the control group. Additionally, patients in heroin group show statistically significant (p=0.01) lower sleep efficiency (63.14±15.1 vs. 75.1±13.28) and higher number of awakenings in comparison to control group. Furthermore, they also show higher N1% (p=0.027) and lower N3% (p=0.036) of total sleep time in comparison to control group, duration of last abstinence period from heroin use disorder has a statistically significant (p=.007) strong negative correlation (r=-.586) with total sleep time. Additionally, duration of the time lasted since last abstinence from heroin has a statistically significant (p=.036) strong negative correlation (r=-.471) with N3% of total sleep time. Conclusion Heroin use disorder is associated with lower total sleep time, sleep efficiency, higher number of awakenings, higher N1% and lower N3% of total sleep time and longer sleep onset in comparison to the control group.