EFFECT OF TETRACYCLINE ON POSTOPERATIVE PAIN AND WOUND HEALING: A COMPARATIVE PROSPECTIVE STUDY

Abstract

Background: The anti-inflammatory nature of tetracycline can be useful in the reduction of postoperative sequelae following extraction. It has also been reported that, gelatin sponge too reduces postoperative complications after oral surgical wounds. Gelatin sponge serves as a mechanical hemostatic agent which obliterates dead space which hastens healing of wound.

Aim and objectives: this study aims towards the effect of tetracycline capsule on postoperative pain and wound.

Methodology: Seventy-two patients requiring mandibular teeth extraction of the age group of 18 and above who reported to the Department of Oral and Maxillofacial Surgery, from January 2022 to April 2022 were included in the study. A small piece of collagen membrane was used on the superior surface of the socket after placement of the medicament ( Tetracycline+Gelatin Sponge). Pain and status of wound healing was recorded after 1 day,7days and 14 days postoperatively. Systemic antibiotics were nit prescribed in any of the group, in Control group, patients were given oral analgesics ( Tab Zerodol sp) twice daily for 3 days and from first postoperative day onward whereas in the Treatment group, oral analgesics were given SOS.

Results: Comparison made on the 1^st day showed statistically significant correlation between the study (2.19±0.401) and control group (2.00±0.00) (p=0.005). On the 7^th day, comparison made between the groups showed statistically significant correlation between the study (4.22±0.591) and control group (3.28±0.882) (p<0.0001). After 14 days, comparison made between the groups showed statistically significant correlation between the study (5.00±0.00) and control group (4.78±0.422) (p=0.002).

Conclusion: The present study concludes that tetracycline compound placement after the surgical extraction of mandibular tooth yielded less pain and inflammation than in the controls who received no such treatment.