THE EFFECT OF HEMODIALYSIS SESSIONS ON VISFATIN, IL-6, TNF-ALPHA, VITAMIN-D AND SEVERAL BIOCHEMICAL PARAMETER IN PATIENTS WITH END STAG OF RENAL FAILURE IN RAMADI TEACHING HOSPITAL

Abstract

Objectives: Adipokines, Cytokines and Biochemical parameters in patients’ blood are very important indicator of the health status of patients with chronic kidney failure who undergoing dialysis.

Methods: In this study taken 600 blood samples from 100 patients, immediately in patients undergoing hemodialysis before and after three dialysis sessions, and then tested it for Visfatin, IL-6, TNF-alpha and Vitamin-D with 20 biochemical parameter.

Results: The results showed that the levels of serum interleukin-6, tumor necrosis factor-a, Visfatin, Cholesterol, TG, amylase and ALP, significantly increased in patients before and after three dialysis sessions compared to healthy group, correspondingly the level of direct Bilirubin recorded no significant difference before and after three dialysis sessions comparing with control group. On the other hand, the results indicated a significant decreased in serum Vitamin-D, albumin, HDL, Ca+2, Na+, AST, ALT and T.Bilirubin.Serum Urea, Creatinine, K+, Glucose and U.A, recorded a significant increase before dialysis while a significant decrease for S.TP  compared with the control group. The results revealed the ability of dialysis membranes to change the levels of parameters after dialysis to 3 groups, first group showed a significant increase as S.LDH and second group showed a significanr decrease as S.UA, S.K+ and Cl-, finally the third group exhibited no significand difference comparing with control group as S.Urea, S.Creatinine and S.Glucose.The results demonstrate that there is a significant positive correlation between Interleukin-6, Tumor necrosis factor-a and Visfatin with each other, whereas a significant negative correlation between Vitamin-D with Interleukin-6, Tumor necrosis factor-a and Visfatin.

Conclusion: The study concluded that increased circulating serum Visfatin, Interleukin-6 and Tumor necrosis factor-a, dyslipidemia and electrolytes disturbances with Vitamin-D deficiency in CKD patients at 3-dialysis stage, probably promotes progression of renal disease and could contribute to accelerate the atherosclerosis and cardiovascular disease and may increase the morbidity and mortality in these groups of patients.