TO ENHANCE THE SOLUBILITY OF IVERMECTIN WITH PHYSICAL MIXING METHOD FOR THE PREPARATION OF ORODISPERSIBLE TABLETS

Abstract

This study was aimed to enhance solubility of ivermectin and developed the orodispersable tablet (ODT) in solid unit dosage forms which
administer orally it is dissolve and disintegrate instantly within few seconds. Fast disintegrating tablet is useful for paediatric, geriatric, it
improve the patient compliance. In this article the ivermectin fast disintegrating tablet were prepared by using superdisintegrant ingredient
like cross carmellose sodium. The solubility of ivermectin was enhanced by using solid dispersion techniques in these technique PEG 600
are used it increased the solubility of FDT. Total 06 formulation prepared and evaluated. And the formulation F2 was shown best result as
per ICH guideline. Optimized formulation F2 contained cross carmallose sodium and show better result in disintegration time 16 sec and
maximum in vitro drug release of FDT is 98 %.